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1204669-62-4

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1204669-62-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1204669-62-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,4,6,6 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1204669-62:
(9*1)+(8*2)+(7*0)+(6*4)+(5*6)+(4*6)+(3*9)+(2*6)+(1*2)=144
144 % 10 = 4
So 1204669-62-4 is a valid CAS Registry Number.

1204669-62-4Relevant articles and documents

INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION

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Paragraph 0109-0111, (2019/02/19)

The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an application. The IDO inhibitor is an N′-hydroxyl-N-phenylformamidine derivative, which has a high inhibito

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

Fang, Kun,Dong, Guoqiang,Wang, Hongyu,He, Shipeng,Wu, Shanchao,Wang, Wei,Sheng, Chunquan

supporting information, p. 30 - 36 (2017/12/26)

Herein we report the first exploration of a dual-targeting drug design strategy to improve the efficacy of small-molecule cancer immunotherapy. New hybrids of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and DNA alkylating nitrogen mustards that respectively target IDO1 and DNA were rationally designed. As the first-in-class examples of such molecules, they were found to exhibit significantly enhanced anticancer activity in vitro and in vivo with low toxicity. This proof-of-concept study has established a critical step toward the development of a novel and effective immunotherapy for the treatment of cancers.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE

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Page/Page column 19; 22, (2017/01/23)

Provided are compounds of formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the prog

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