120510-52-3

Basic information

• Product Name: 2-Pyridinemethanol, 6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-
• CAS NO: 120510-52-3
• Molecular Formula: C28H27NO4
• Molecular Weight: 441.527
• Mol File: 120510-52-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Pyridinemethanol, 6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanol, 6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-(120510-52-3)
• EPA Substance Registry System: 2-Pyridinemethanol, 6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-(120510-52-3)

Safety Data

• Hazardous Substances Data: 120510-52-3(Hazardous Substances Data)

Upstream product

• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 

Downstream Products

• 180720-40-5 1-[(2-cyanoethyloxy)(N,N-diisopropylamino)phosphinyloxymethyl]-3-(4,4'-dimethoxytrityloxymethyl)pyridine 
• 946842-31-5 C₃₂H₃₁NO₇ 
• 129242-87-1 {6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-pyridin-2-ylmethoxy}-acetic acid methyl ester 

Relevant articles and documents

AROMATIC COMPOUND, MODIFICATION CARRIER THAT USES SAME AND IS USED FOR SYNTHESIZING AN OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE DERIVATIVE, AND OLIGONUCLEOTIDE CONSTRUCT

The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.

Synthesis and properties of combinatorial libraries of phosphoramidates

We have assembled a set of combinatorial libraries of phosphoramidates for pharmacological evaluation. A range of functionalized and unfunctionalized diols, representing a variety of diversity elements, were converted into their corresponding dimethoxytrityl H-phosphonate derivatives which were coupled to each other to produce H-phosphonate dimers and trimers. The H-phosphonate diesters were converted into phosphoramidates by reaction with a wide range of primary and secondary amines. Very large libraries (theoretically, in excess of one million compounds) possessing five sites of diversity were generated for use in our drug discovery program. Smaller libraries with lower molecular weights were also prepared in which only two monomeric units were coupled together and converted into their phosphoramidate derivatives. Methods for the attachment of both radioactive and nonradioactive labels, including 32phosphorus, tritium, and fluorescein, have been developed. Representative single sequences were also prepared and their chemical properties studied.