120511-91-3

Basic information

• Product Name: 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE
• Synonyms: 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE;Anastrozole EP Impurity I
• CAS NO: 120511-91-3
• Molecular Formula: C₁₅H₁₇ClN₂
• Molecular Weight: 260.76188
• Mol File: 120511-91-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE(120511-91-3)
• EPA Substance Registry System: 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE(120511-91-3)

Safety Data

• Hazardous Substances Data: 120511-91-3(Hazardous Substances Data)

Usage

Description

2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE is a complex organic compound characterized by its unique molecular structure. It is a derivative of nitriles, which are known for their diverse range of applications in various industries. This specific compound is distinguished by its chloromethyl and cyano groups, as well as its dimethyl-methyl-phenyl moiety, which contribute to its potential uses and properties.

Uses

Used in Pharmaceutical Industry:
2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly in the field of oncology.
Used in Antineoplastic Drug Development:
In the pharmaceutical industry, 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE is used as a building block for the creation of antineoplastic agents. It plays a crucial role in the development of drugs that target cancer cells, such as aromatase inhibitors like Anastrozole (A637425), which is used in post-menopausal women with advanced breast cancer.
Used in Chemical Research:
2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE is also utilized in chemical research as a starting material for the synthesis of various organic compounds. Its versatile structure makes it a valuable asset in the development of new molecules with potential applications in various fields, including materials science, agrochemistry, and environmental science.

Upstream product

• 120511-88-8 2-[3-(cyano-dimethyl-methyl)-5-hydroxymethyl-phenyl]-2-methyl-propionitrile 

Downstream Products

• 120511-73-1 anastrozol 
• 120511-92-4 α,α,α',α'-tetramethyl-5-(4H-1,2,4-triazol-4ylmethyl)-1,3-benzene-diacetonitrile 

Relevant articles and documents

PROCESS FOR PURIFICATION OF ANASTROZOLE

Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both.

PHENYL-SULFAMATES AS AROMATASE INHIBITORS

There is provided a compound of Formula (I) wherein X, Y and Z are each independently of each other an optional linker group; R, is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (CN), nitro (-NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.