120546-68-1Relevant articles and documents
Tetrahydrothiadiazoloisoquinolines: Synthesis and inhibition of phenylethanolamine-N-methyltransferase
Girard,Bondinell,Hillegass,Holden,Pendleton,Uzinskas
, p. 1566 - 1571 (2007/10/02)
A series of 7,8-fused heterocyclic tetrahydroisoquinolines were synthesized and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). 6,7,8,9-Tetrahydro[1,2,3]thiadiazolo[5,4-h]isoquinoline 5 (SK and F 86607) was found to b