120577-33-5 Usage
Description
(R)-N-((S)-1-phenylethyl)quinuclidin-3-aMine is a chiral chemical compound belonging to the class of quinuclidine derivatives. It features a stereocenter at the nitrogen atom, resulting in two enantiomeric forms, (R) and (S). (R)-N-((S)-1-phenylethyl)quinuclidin-3-aMine has demonstrated potential biological activity and is of interest for its pharmacological properties, particularly as a cholinergic agonist. Its unique structure and properties make it a promising candidate for various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(R)-N-((S)-1-phenylethyl)quinuclidin-3-aMine is used as a potential therapeutic agent for neurological conditions such as Alzheimer's disease and Parkinson's disease. Its cholinergic agonist properties make it a candidate for the development of drugs that can help improve cognitive function and alleviate symptoms associated with these conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-N-((S)-1-phenylethyl)quinuclidin-3-aMine is used as a key compound in the synthesis of novel drugs targeting the cholinergic system. Its unique structure allows for the exploration of new drug candidates with potential applications in treating various neurological disorders.
Used in Organic Synthesis:
(R)-N-((S)-1-phenylethyl)quinuclidin-3-aMine also has applications in organic synthesis, where it can serve as a building block or intermediate for the creation of more complex molecules with diverse biological activities. Its chiral nature and unique structural features make it a valuable component in the development of new pharmaceuticals and other bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 120577-33-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,7 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 120577-33:
(8*1)+(7*2)+(6*0)+(5*5)+(4*7)+(3*7)+(2*3)+(1*3)=105
105 % 10 = 5
So 120577-33-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H22N2/c1-12(13-5-3-2-4-6-13)16-15-11-17-9-7-14(15)8-10-17/h2-6,12,14-16H,7-11H2,1H3/t12-,15-/m0/s1
120577-33-5Relevant articles and documents
Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues
De Paulis,Hewlett,Schmidt,Mason,Trivedi,Ebert
, p. 385 - 396 (2007/10/03)
(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.
Heterocyclic compounds useful as 5-HT3 antagonists
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, (2008/06/13)
Aroyl ureas and carbamic acid derivatives of formula and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including optionally substituted phenyl W is O or S Y is NH or S and B is a specified saturated azacyclic ring, eg tropan-3-yl or quinuclidin-3-yl, possess 5-HT3 -antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.
