120636-88-6

Basic information

• Product Name: L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-
• CAS NO: 120636-88-6
• Molecular Formula: C20H31N3O4
• Molecular Weight: 377.484
• Mol File: 120636-88-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-(120636-88-6)
• EPA Substance Registry System: L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-(120636-88-6)

Safety Data

• Hazardous Substances Data: 120636-88-6(Hazardous Substances Data)

Upstream product

• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 13139-16-7 N-tert-butyloxy-isoleucine 
• 3392-08-3 tert-(butoxycarbonyl)isoleucine succinimidyl ester 
• 5241-58-7 L-Phenylalanine amide 

Downstream Products

• 102638-71-1 2-amino-3-methylpentanoci acid (1-carbamoyl-2-phenylethyl)amide 
• 126409-58-3 {(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 102638-71-1 (S)-2-Amino-3-methyl-pentanoic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide 
• 1028301-09-8 ((R)-1-{[(1S,2S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butylamino]-methyl}-2-tritylsulfanyl-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Sidechain-linked inhibitors of HIV-1 protease dimerization

There is a great need for alternative modes of inhibition for the design of anti-HIV therapies, due to the increased resistance of HIV to currently approved drugs. A novel strategy for generating potent dimerization inhibitors of HIV-1 protease is describ

Peptide inhibitors of aspartic proteinases with hydroxyethylene isostere replacement of peptide bond. II. Preparation of pseudotetrapeptides derived from diastereoisomeric 5-amino-2-benzyl-4-hydroxy-6-phenylhexanoic acids

Twelve pseudotetrapeptides, Boc-NHCH(CH2Ph)CH(OH)CH2CH(CH2Ph) CO-Xaa-Phe-NH2 9-11, were prepared by [(benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphatemediated couplings of diastereoisomer

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were tested as inhibitors of virus spread in cell culture. Compound 12 was a 10-fold more potent enzyme inhibitor than 1 in vitro and 30-fold more potent in inhibiting the viral spread in cells.