1206456-44-1 Usage
Description
Olopatadine Isopropyl ester Hydrochloride is an intermediate compound used in the synthesis of Olopatadine, a pharmaceutical agent with dual action as a histamine H1-receptor antagonist and mast cell stabilizer.
Used in Pharmaceutical Industry:
Olopatadine Isopropyl ester Hydrochloride is used as an intermediate in the preparation of Olopatadine (O575000, HCl salt) via Wittig reaction for its dual action as a histamine H1-receptor antagonist and mast cell stabilizer. This dual action makes Olopatadine effective in treating allergic conditions such as rhinitis and conjunctivitis, providing relief from symptoms like itching, redness, and swelling.
Check Digit Verification of cas no
The CAS Registry Mumber 1206456-44-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,4,5 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1206456-44:
(9*1)+(8*2)+(7*0)+(6*6)+(5*4)+(4*5)+(3*6)+(2*4)+(1*4)=131
131 % 10 = 1
So 1206456-44-1 is a valid CAS Registry Number.
1206456-44-1Relevant articles and documents
Process for obtaining olopatadine and intermediates
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Page/Page column 14-15, (2010/02/17)
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Witting reagent, in the presence of a base in a reaction medium comprising an organic solvent.
