1206482-78-1Relevant articles and documents
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
Lim, Carine S.Q.,Ha, Kam Pou,Clarke, Rebecca S.,Gavin, Leigh-Anne,Cook, Declan T.,Hutton, Jennie A.,Sutherell, Charlotte L.,Edwards, Andrew M.,Evans, Lindsay E.,Tate, Edward W.,Lanyon-Hogg, Thomas
supporting information, (2019/07/16)
The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore sou
PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS
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Page/Page column 17; 22, (2011/05/11)
Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.