1206640-82-5

Basic information

• Product Name: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• Synonyms: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(difluoroMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-y;1-(difluoromethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(Difluoromethyl)pyrazole-4-boronic acid pinacol ester;(1-(DIFLUOROMETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1206640-82-5
• Molecular Formula: C₁₀H₁₅BF₂N₂O₂
• Molecular Weight: 244.0461064
• Mol File: 1206640-82-5.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 294.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.01±0.19(Predicted)
• CAS DataBase Reference: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(1206640-82-5)
• EPA Substance Registry System: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(1206640-82-5)

Safety Data

• Hazardous Substances Data: 1206640-82-5(Hazardous Substances Data)

Usage

General Description

"1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole" is a chemical compound that is primarily known for its use in the field of synthetic organic chemistry. 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is characterized by its unique structure which includes 1H-pyrazole ring and a 1,3,2-dioxaborolan-2-yl unit. The presence of a difluoromethyl group makes it potentially useful for various fluorination strategies. However, specific properties, such as solubility, melting point, or boiling point, as well as its potential hazards or safe handling procedures, largely depend on the specific conditions of synthesis and are not typically summarized in the chemical name itself.

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 75-45-6 Chlorodifluoromethane 
• 1895-39-2 sodium chlorodifluoroacetate 
• 956477-67-1 4-bromo-1-(difluoromethyl)-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Downstream Products

• 1238697-10-3 1-{4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-2-fluorophenyl}-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 

Relevant articles and documents

PYRAZOLOTRIAZINES

The present invention provides compounds of general formula (I), in which X, R1, R2 and R3 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders such as cancer disorders, as a sole agent or in combination with other active ingredients.

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.