120667-15-4 Usage
Uses
(RS)-PPG is a potent and selective group III mGluR agonist.
Biological Activity
A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu 8 ; anticonvulsant and neuroprotective in vivo . Also available as part of the Group III mGlu Receptor Tocriset? .
Check Digit Verification of cas no
The CAS Registry Mumber 120667-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,6,6 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120667-15:
(8*1)+(7*2)+(6*0)+(5*6)+(4*6)+(3*7)+(2*1)+(1*5)=104
104 % 10 = 4
So 120667-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H10NO5P/c10-8(11)5-9-6-1-3-7(4-2-6)15(12,13)14/h1-4,9H,5H2,(H,10,11)(H2,12,13,14)
120667-15-4Relevant articles and documents
(+)-4-Phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
Gasparini, Fabrizio,Inderbitzin, Werner,Francotte, Eric,Lecis, Gabrielle,Richert, Paul,Dragic, Zorica,Kuhn, Rainer,Flor, Peter J.
, p. 1241 - 1244 (2007/10/03)
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.
