1207175-68-5

Basic information

• Product Name: 7-bromo-3,4-dihydroquinazolin-2(1H)-one
• Synonyms: 7-bromo-3,4-dihydroquinazolin-2(1H)-one;7-BroMo-3,4-dihydro-2(1H)-quinazolinone;7-Bromo-3,4-dihydroquinazolin-2(1H)
• CAS NO: 1207175-68-5
• Molecular Formula: C8H7BrN2O
• Molecular Weight: 227
• Mol File: 1207175-68-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 294.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.610
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.11±0.20(Predicted)
• CAS DataBase Reference: 7-bromo-3,4-dihydroquinazolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-3,4-dihydroquinazolin-2(1H)-one(1207175-68-5)
• EPA Substance Registry System: 7-bromo-3,4-dihydroquinazolin-2(1H)-one(1207175-68-5)

Safety Data

• Hazardous Substances Data: 1207175-68-5(Hazardous Substances Data)

Usage

General Description

7-bromo-3,4-dihydroquinazolin-2(1H)-one is a heterocyclic compound with a quinazolinone backbone that contains a bromine atom at the 7th position. It is a synthetic chemical that has potential pharmaceutical applications, particularly as a building block in the synthesis of various therapeutic agents. The presence of the bromine functional group makes this compound useful in chemical reactions to introduce other substituents, thereby allowing for the creation of diverse molecular structures. Additionally, its quinazolinone core provides biochemical versatility, potentially enabling the development of novel drugs or research tools. Overall, 7-bromo-3,4-dihydroquinazolin-2(1H)-one is a valuable chemical compound with promising applications in medicinal and chemical research.

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Downstream Products

• 1630951-37-9 7-(1-(biphenyl-4-ylmethyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-38-0 7-(1-((4'-fluorobiphenyl-4-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-39-1 7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-40-4 7-(1-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-41-5 7-(1-(3-cyclopentenylbenzyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one 

Relevant articles and documents

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones

A series of new 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H) -ones has been synthesized. The described compounds are structurally related to adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. Suitably modified aryl bromides were prepared and condensed with tert-butyl piperazine-1-carboxylate to afford the advanced intermediate piperazinyl-3,4-dihydroquinazolin-2(1H)-one. Likewise Suzuki-Miyaura cross-coupling reaction of cyclic vinyl boronate with appropriate aryl bromides rendered piperidinyl-3,4-dihydroquinazolin-2(1H)-one. The reductive amination of the piperazinyl and piperidinyl-3,4- dihydroquinazolin-2(1H)-ones with suitably designed biarylaldehydes accomplished the synthesis of these title compounds. The described compounds were screened for D2 and 5-HT1A receptors binding affinities. The structure-activity relationship studies revealed that cyclopentenylpyridine and cyclopentenylbenzyl groups contribute significantly to the dual D2 and 5-HT1A receptor binding affinities of these compounds.