1207429-58-0

Basic information

• Product Name: 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole
• Synonyms: 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole
• CAS NO: 1207429-58-0
• Molecular Weight: 297.664
• Mol File: 1207429-58-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole(1207429-58-0)
• EPA Substance Registry System: 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole(1207429-58-0)

Safety Data

• Hazardous Substances Data: 1207429-58-0(Hazardous Substances Data)

Upstream product

• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 17200-29-2 5-chloro-benzoxazole 
• 1139705-23-9 3-(trifluoromethyl)phenyl 1H-imidazole-1-sulfonate 

Relevant articles and documents

Base-promoted formal arylation of benzo[d]oxazoles with acyl chloride

A base-promoted formal arylation of benzo[d]oxazoles with acyl chloride was achieved in moderate to good yields. This reaction was triggered by the N-acylation of oxazole to form an iminium intermediate. Then, the addition of H2O to the iminium formed the hemiacetal intermediate. After the sequential ring-opening, extrusion of CO, the ring closure, the dehydration delivered the formal arylation product. In comparison with the transition-metal-catalyzed methodology, it represents an alternative arylation method leading to 2-arylbenzooxazole.