120777-22-2

Basic information

• Product Name: PHENYLPYRROLE-3-CARBOXALDEHYDE NSUBSTITUTED
• Synonyms: PHENYLPYRROLE-3-CARBOXALDEHYDE NSUBSTITUTED;1-Phenyl-1H-pyrrole-3-carbaldehyde
• CAS NO: 120777-22-2
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 120777-22-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYLPYRROLE-3-CARBOXALDEHYDE NSUBSTITUTED(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYLPYRROLE-3-CARBOXALDEHYDE NSUBSTITUTED(120777-22-2)
• EPA Substance Registry System: PHENYLPYRROLE-3-CARBOXALDEHYDE NSUBSTITUTED(120777-22-2)

Safety Data

• Hazardous Substances Data: 120777-22-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 1855, 1994 DOI: 10.1080/00397919408010193

Upstream product

• 332-77-4 2,5-dihydro-2,5-dimethoxyfuran 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 30186-39-1 N-phenylpyrrole-2-carbaldehyde 
• 161297-62-7 Z-N-methylanilinomethylene-N'-phenylsuccinimide 
• 50634-05-4 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde 
• 635-90-5 1-phenylpyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 7126-39-8 pyrrole-3-carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 941-69-5 N-phenyl-maleimide 
• 4497-57-8 2,2,4-trimethyl-3,4-dihydroquinoline-1(2H)-carbaldehyde 
• 2700-30-3 N,N-diisorpopylformamide 
• 607-00-1 diphenylformamide 

Downstream Products

• 65735-06-0 1-phenyl-1H-pyrrole-3-carbonitrile 
• 99972-42-6 1-phenyl-1H-pyrrole-3-carboxylic acid 
• 178809-91-1 (E)-2-nitro-1-(N-phenylpyrrol-3-yl)prop-2-ene 
• 163560-68-7 3-benzyloxycarbonylamino-1-phenylpyrrole 
• 691863-28-2 5-aminomethyl-3-(1-phenyl-1H-pyrrol-3-yl)-oxazolidin-2-one 
• 163560-69-8 3-amino-1-phenylpyrrole 
• 220968-56-9 1-Phenyl-1H-pyrrole-3-carbonyl chloride 
• 163560-67-6 1-phenylpyrrole-3-carboxylic acid azide 
• 174823-27-9 1-phenyl-3[(4-benzylpiperidin-1-yl)methyl]pyrrole 

Relevant articles and documents

Asymmetric biocatalytic hydrocyanation of pyrrole carboxaldehydes

The asymmetric hydrocyanation of pyrrole-2- and -3-carboxaldehydes substituted with either methyl, benzyl or phenyl in the 1-position catalyzed by the hydroxynitrile lyases from Hevea brasiliensis (HbHNL) and Prunus amygdalus (PaHNL) is reported. The products could be isolated - after O-silylation - with moderate to good enantiomeric purity although the carbonyl activity of the substrates was found to be very low, which is supported by quantum-chemical calculations. Structural effects concerning substrate size and regiochemistry are discussed considering docking calculations based on the X-ray crystal structures of the two enzymes. From these calculations one particular amino acid residue (Trp-128) in the active site of HbHNL could be identified, which plays a major role for the appropriate binding of structurally demanding carbonyl compounds.

1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding

A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 recep

Direct and efficient synthesis of pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles with sterically crowded amides

A simple and convenient synthetic method to prepare N-substituted pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles using sterically crowded formamides was developed. The dependence of the formylation regioselectivity on steric features of substrates and reagents is discussed. Georg Thieme Verlag Stuttgart · New York.

NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND

The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].