1210360-60-3

Basic information

• Product Name: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
• Synonyms: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione;3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione,99%e.e.
• CAS NO: 1210360-60-3
• Molecular Formula: C₃₃H₃₀F₆N₄O₃
• Molecular Weight: 644.61
• Mol File: 1210360-60-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 664.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 9.24±0.70(Predicted)
• CAS DataBase Reference: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione(1210360-60-3)
• EPA Substance Registry System: 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6'-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione(1210360-60-3)

Safety Data

• Hazardous Substances Data: 1210360-60-3(Hazardous Substances Data)

Upstream product

• 1073917-05-1 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-methoxycyclobut-3-ene-1,2-dione 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 85068-29-7 3,5-bis-trifluoromethylbenzylamine 
• 168778-61-8 (8S,9S)-9-azido-(9-deoxy)epiquinine 
• 249731-47-3 9-mesylquinine 

Relevant articles and documents

Self-assembled fibrillar networks of a multifaceted chiral squaramide: Supramolecular multistimuli-responsive alcogels

Chiral N,N′-disubstituted squaramide 1 has been found to undergo self-assembly in a variety of alcoholic solvents at low concentrations leading to the formation of novel nanostructured supramolecular alcogels. The gels responded to thermal, mechanical, op

Enantioselective Synthesis of Cyclohexenol Derivatives from ?-Aryl-Substituted Enals via an Organocatalyzed Three-Component Reaction

A three-component reaction between ?-aryl-substituted α,β-unsaturated aldehydes and nitroalkenes was realized by using cinchona alkaloid-derived (thio)ureas and squaramides via the dienolate intermediates. This unprecedented 1,3- A nd 1,5-reactivity of dienolates of the ?-aryl-α,β-unsaturated aldehydes led to the formation of cyclohexenol derivatives with four contiguous stereogenic centers and a chiral substituent at C2 with good diastereoselectivities and high ee values. Such reactivities of the dienolates are totally different from those of the corresponding dienamine intermediates.

Total Syntheses of Pyroclavine, Festuclavine, Lysergol, and Isolysergol via a Catalytic Asymmetric Nitro-Michael Reaction

A catalytic enantioselective construction of vicinal stereocenters is reported. The reaction takes advantage of thiourea-catalyzed intramolecular nitronate addition onto α,β-unsaturated ester to afford exceptional levels of enantioselectivity (up to 97 % ee) with moderate diastereoselectivity (up to 4:1). Using this method, a cross-conjugated ester was synthesized in few steps, from which a 6-endo-trig cyclisation led to the formation of all required functionalities for total syntheses of ergot alkaloids. The strategy not only offers first total syntheses of ergot alkaloids, festuclavine (1 c), and pyroclavine (1 e), and but also an efficient and general approach to other congeners such as, lysergol (1 b), and isolysergol (1 d).