1210451-25-4

Basic information

• Product Name: N-[5-(3,5-bis-trifluoromethyl-phenylsulfanyl methyI)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yl]-N-methyI-methanesulfonamide
• Synonyms: N-[5-(3,5-bis-trifluoromethyl-phenylsulfanyl methyI)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yl]-N-methyI-methanesulfonamide
• CAS NO: 1210451-25-4
• Molecular Weight: 581.578
• Mol File: 1210451-25-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[5-(3,5-bis-trifluoromethyl-phenylsulfanyl methyI)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yl]-N-methyI-methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(3,5-bis-trifluoromethyl-phenylsulfanyl methyI)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yl]-N-methyI-methanesulfonamide(1210451-25-4)
• EPA Substance Registry System: N-[5-(3,5-bis-trifluoromethyl-phenylsulfanyl methyI)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yl]-N-methyI-methanesulfonamide(1210451-25-4)

Safety Data

• Hazardous Substances Data: 1210451-25-4(Hazardous Substances Data)

Upstream product

• 799842-07-2 N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide 
• 130783-02-7 3,5-bis(trifluoromethyl)thiophenol 

Downstream Products

• 1210451-28-7 N-[5-(3,5-bis-trifluoromethyl-benzenesulfonyl methyl)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yI]-N-methyl-methanesulfonamide 

Relevant articles and documents

Highly stereoselective formal synthesis of rosuvastatin and pitavastatin through Julia-Kocienski olefination using the lactonized statin side-chain precursor

An expedient and simple synthetic approach to pitava statin and rosuvastatin final intermediates is described. The presented approach consists of completely stereoselective Julia-Kocienski olefination step (E/Z up to 300:1) between lactonized statin side-chain precursor and sulfone derivative of the corresponding pyrimidine and quinoline heterocyclic cores. The desired O-TBS protected statin lactones were isolated in 66-71% yield and high >97% purity (HPLC). Georg Thieme Verlag Stuttgart. New York.