121056-98-2

Basic information

• Product Name: Benzenemethanol, 3,4,5-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS NO: 121056-98-2
• Molecular Formula: C25H50O4Si3
• Molecular Weight: 512.91
• Mol File: 121056-98-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3,4,5-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,4,5-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(121056-98-2)
• EPA Substance Registry System: Benzenemethanol, 3,4,5-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(121056-98-2)

Safety Data

• Hazardous Substances Data: 121056-98-2(Hazardous Substances Data)

Upstream product

• 121056-97-1 methyl 3,4,5-tris<(tert-butyldimethylsilyl)oxy>benzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-24-1 methyl galloate 
• 121056-86-8 3,4,5-tris((tert-butyldimethylsilyl)oxy)benzaldehyde 
• 99-06-9 3-Carboxyphenol 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 487-70-7 2,4,6-trihydroxybenzaldehyde 
• 853687-37-3 (-)-ECG-7TBS 
• 265975-35-7 2,4,6-tri-tert-butyldimethylsilyloxybenzaldehyde 
• 185462-50-4 tert-butyldimethylsilyl 3,4,5-tri[(tert-butyldimethylsilyl)oxy]benzoate 

Downstream Products

• 853687-50-0 N-[2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-chroman-3-yl]-3,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-benzamide 
• 853687-49-7 N-[2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-chroman-3-yl]-3,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-benzamide 
• 1399278-27-3 C₃₉H₆₄O₁₀Si₃ 
• 1399278-24-0 methyl 4,6-O-benzylidene-2,3-bis[3,4,5-tris((tert-butyldimethylsilyl)oxy)]benzoyl-α-D-glucopyranoside 
• 1399278-21-7 2-nitrobenzyl 4,6-O-benzylidene-2,3-bis[3,4,5-tris((tert-butyldimethylsilyl)oxy)]benzoyl-β-D-glucopyranoside 
• 1426058-16-3 2-(3,4,5-tris(dodecyloxy)benzyl)isoindoline-1,3-dione 
• 752771-80-5 (3,4,5-tris(dodecyloxy)phenyl)methanamine 
• 1426058-09-4 2-(3,4,5-trihydroxybenzyl)isoindoline-1,3-dione 
• 1131849-97-2 C₃₉H₇₀O₄Si₄ 
• 1131849-93-8 C₃₉H₇₀O₄Si₄ 

Relevant articles and documents

Intrinsic charge carrier mobilities at InsulatorSemiconductor interfaces probed by microwave-based techniques: Studies with liquid crystalline organic semiconductors

The intrinsic, local-scale hole and electron mobilities at the interface between perylenediimide (PDI)-based liquid crystalline organic semiconductors and insulating polymers were evaluated by field-induced time-resolved microwave conductivity (FITRMC). T

One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1

Pancreatic triglyceride lipase (PTL) and Niemann-Pick C1-like 1 (NPC1L1) have been identified as attractive therapeutic targets for obesity and hypercholesteremia, respectively. Obesity and hypercholesteremia usually co-exist, however no dual-inhibitors against PTL and NPC1L1 were reported for the treatment of obesity patients with hypercholesteremia so far. In this work, molecular hybridization-based one-step modification screening identified a potent dual-inhibitor against PTL and NPC1L1. Compound P1-11 has IC50 values of 2.1 μM against PTL through covalent binding, as well as significantly reduces cholesterol absorption in a non-competitive inhibitory manner. Molecule docking and molecular dynamics studies revealed the reason of its activity to both PTL and NPC1L1. Moreover, the gene and protein expression levels of PTL and NPC1L1 were also determined respectively after the treatment of P1-11. Development of dual-inhibitors against PTL and NPC1L1 could provide novel treatment options for obesity patients with hypercholesteremia. The results of current research would great support the development of dual-inhibitors against PTL and NPC1L1.

Understanding the regioselectivity in the oxidative condensation of catechins using pyrogallol-type model compounds

Catechins are found in many foods, including tea. These compounds are bioactive. Previous studies have shown that catechins form dimers on oxidation, and there seem to be distinct regioselective effects. However, the dimerization mechanism and regioselectivity are not well understood. Therefore, we investigated the oxidation of four pyrogallol-type model compounds of epigallocatechin (EGC) having various substituents with 1 equiv of copper chloride and 30% dioxane in water. Compounds having 2C-2C or 2C-4C bonds in the B-ring were obtained in different product ratios. Comparison of the oxidation rates of each compound revealed that the model compounds having an oxygen atom corresponding to the 1-position of the C-ring of EGC underwent slow oxidation. In addition, using density functional theory calculations, we found that the highest occupied molecular orbital energies of these compounds were higher than those of the others. Further, the 2C-2C-bonded oxidation product having an A-ring and an oxygen atom at the C-ring 1-position was confirmed to have the highest thermodynamic stability. From these results, it is suggested that the regioselective condensation reaction of the catechin B-ring is related to interactions between the A-rings, as indicated by earlier studies, and the presence of oxygen at the 1-position of the C-ring in EGC.