1210868-14-6

Basic information

• Product Name: 2-(benzylsulfanyl)-5-methoxypyridine
• Synonyms: 2-(benzylsulfanyl)-5-methoxypyridine
• CAS NO: 1210868-14-6
• Molecular Weight: 231.318
• Mol File: 1210868-14-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(benzylsulfanyl)-5-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzylsulfanyl)-5-methoxypyridine(1210868-14-6)
• EPA Substance Registry System: 2-(benzylsulfanyl)-5-methoxypyridine(1210868-14-6)

Safety Data

• Hazardous Substances Data: 1210868-14-6(Hazardous Substances Data)

Upstream product

• 139585-48-1 2-chloro-5-methoxypyridine 
• 100-51-6 benzyl alcohol 
• 105170-27-2 2-bromo-5-methoxypyridine 
• 100-53-8 phenylmethanethiol 

Downstream Products

• 1060801-83-3 5-methoxypyridine-2-sulfonyl chloride 

Relevant articles and documents

Promoting Effect of Crystal Water Leading to Catalyst-Free Synthesis of Heteroaryl Thioether from Heteroaryl Chloride, Sodium Thiosulfate Pentahydrate, and Alcohol

It is observed the crystal water in sodium thiosulfate pentahydrate (Na2S2O3·5H2O) can promote its multicomponent reaction with heteroaryl chlorides and alcohols, providing a facile, green, and specific synthesis of unsymmetrical heteroaryl thioethers via one-step formation of two C-S bonds under catalyst-, additive-, and solvent-free conditions. Mechanistic studies suggest that the crystal water in Na2S2O3·5H2O is crucial in generating the key thiol intermediates and byproduct NaHSO4, which then catalyzes the dehydrative substitution of alcohols with thiols to afford thioethers.

Efficient Generation of C–S Bonds via a By-Product-Promoted Selective Coupling of Alcohols, Organic Halides, and Thiourea

A metal- and base-free three-component coupling of alcohols, heteroaryl halides, and thiourea has been developed for direct and selective synthesis of heteroaryl thioethers. This method can be easily scaled up to the gram scale and extended to dialkyl thioethers, heteroaryl selenides, benzothiazoles, and some antimycobacterially-active thioethers. Mechanistic studies revealed that a by-product-promoted in situ C–O activation of alcohols to more reactive alkyl halides and slow release of the thiol and alkyl halide intermediates are the key to the high selectivity and success of the reaction. (Figure presented.).

PYRROLE COMPOUNDS

The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.