121091-12-1

Basic information

• Product Name: 3,4-dihydro-5-(2-methylphenyl)-2H-pyrrole
• Synonyms: 3,4-dihydro-5-(2-methylphenyl)-2H-pyrrole
• CAS NO: 121091-12-1
• Molecular Weight: 159.231
• Mol File: 121091-12-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,4-dihydro-5-(2-methylphenyl)-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-5-(2-methylphenyl)-2H-pyrrole(121091-12-1)
• EPA Substance Registry System: 3,4-dihydro-5-(2-methylphenyl)-2H-pyrrole(121091-12-1)

Safety Data

• Hazardous Substances Data: 121091-12-1(Hazardous Substances Data)

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 118-90-1 ortho-methylbenzoic acid 
• 87-24-1 ethyl 2-methylbenzoate 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 129540-23-4 2-(2-methylphenyl)pyrrolidine 
• 914299-83-5 (S)-(–)-2-(o-tolyl)pyrrolidine 
• 914299-83-5 (R)-2-(o-tolyl)pyrrolidine 
• 914299-83-5 C₁₁H₁₅N 

Relevant articles and documents

Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines

The intramolecular Csp3-H and/or C-C bond amination is very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. Herein, we report a novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines through selective Csp3-H and/or C-C bond cleavage. Two C-N single bonds or a CN double bond are efficiently constructed in these transformations. The carbocation mechanism differs from the reported metal nitrene intermediates and therefore enables metal-free and new transformation.

Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opioid receptor antagonists

Opioid receptors play an important role in both behavioral and mood functions. Based on the structural modification of LY2456302, a series of aminobenzyloxyarylamide derivatives were designed and synthesized as κ opioid receptor antagonists. The κ opioid receptor binding ability of these compounds were evaluated with opioid receptors binding assays. Compounds 1a-d showed high affinity for κ opioid receptor. Especially for compound 1c, exhibited a significant Kivalue of 15.7?nM for κ opioid receptor binding and a higher selectivity over μ and δ opioid receptors compared to (±)LY2456302. In addition, compound 1c also showed potent κ antagonist activity with κ IC50?=?9.32?nM in [35S]GTP-γ-S functional assay. The potential use of the representative compounds as antidepressants was also investigated. The most potent compound 1c not only exhibited potent antidepressant activity in the mice forced swimming test, but also displayed the effect of anti-anxiety in the elevated plus-maze test.