121138-83-8Relevant articles and documents
Symmetric 4,4′-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators
Sato, Manabu,Ohta, Kiminori,Kaise, Asako,Aoto, Sayaka,Endo, Yasuyuki
, p. 1089 - 1094 (2016)
We designed and synthesized 4,4′-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators. The introduction of hydrophobic substituents on the nitrogen atom of the piperidine ring enhanced ERα binding affinity