1211776-25-8

Basic information

• Product Name: 4-((acridin-9-amino)methyl)benzoic acid
• Synonyms: 4-((acridin-9-amino)methyl)benzoic acid
• CAS NO: 1211776-25-8
• Molecular Weight: 328.37
• Mol File: 1211776-25-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-((acridin-9-amino)methyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((acridin-9-amino)methyl)benzoic acid(1211776-25-8)
• EPA Substance Registry System: 4-((acridin-9-amino)methyl)benzoic acid(1211776-25-8)

Safety Data

• Hazardous Substances Data: 1211776-25-8(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 56-91-7 p-aminomethylbenzoic acid 
• 1207-69-8 9-Chloroacridine 
• 91-40-7 2-(phenylamino)benzoic acid 
• 110166-26-2 aminacrine 
• 619-66-9 4-Carboxybenzaldehyde 

Relevant articles and documents

N-o-substituted phenyl benzamide-4-methylamino acridine compound as well as preparation method and application thereof

The invention discloses an N-o-substituted phenyl benzamide-4-methylamino acridine compound as well as a preparation method and application thereof. The compound is characterized in that the compoundis a compound with a structural formula shown as a formula I or pharmaceutically acceptable salt, ester or solvate thereof, wherein R1 is H, OCH3, OCH2CH3, F, Cl, Br, CF3, NO2 or straight-chain alkylwith a carbon atom number of 1-5; R2 is H, OCH3, OCH2CH3, F, Cl, Br, CF3, NO2 or straight-chain alkyl with a carbon atom number of 1 to 5; R3 is NH2, NHCH3, NHCH2CH3, OH, COOH, and SH, and R4 is H, OCH3 or linear alkyl with 1-5 carbon atoms and the like. The compound has the advantages that the compound can effectively inhibit DNA topoisomerase I, and proliferation of I-type HDAC and/or eukaryotictumor cells, and prevents and/or treats tumors.

One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.