121191-42-2Relevant articles and documents
Introduction of the 4,4,4-Trifluorobut-2-ene Chain Exploiting a Regioselective Tsuji-Trost Reaction Catalyzed by Palladium Nanoparticles
Hemelaere, Rémy,Desroches, Justine,Paquin, Jean-Fran?ois
supporting information, p. 1770 - 1773 (2015/04/14)
A palladium-nanoparticle-catalyzed Tsuji-Trost reaction of 4,4,4-trifluorobut-2-en-1-yl acetate and ethyl(4,4,4-trifluorobut-2-en-1-yl)carbonate was accomplished with various nucleophiles including phenols, amines, and malonates. In the case of the phenols, isomerization of the double bond in the product (up to 20%) was observed as a side reaction. Further synthetic transformations including hydrogenation, the Diels-Alder reaction, and asymmetric dihydroxylation of a product were also examined.
Benzyl alcohol as an alkylating agent using the ruthenium-catalyzed borrowing hydrogen strategy (4,4-dimethyl-3-oxo-2-benzylpentanenitrile)
Nixon, Tracy D.,Slatford, Paul A.,Whittlesey, Michael K.,Williams, Jonathan M. J.,Candito, David A.,Lautens, Mark
scheme or table, p. 28 - 35 (2011/03/19)
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HIV PROTEASE INHIBITORS
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, (2008/06/13)
Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propionyl-valinyl-valinyl methyl ester.