1211939-75-1Relevant articles and documents
A concise enantioselective synthesis of (-)-ranirestat
Trost, Barry M.,Osipov, Maksim,Dong, Guangbin
, p. 1276 - 1279 (2010)
Chemical Equation Presented A concise enantioselective synthesis of the potent aldose reductase inhibitor ranirestat (1) is reported. The synthesis was accomplished employing inexpensive, commercially available starting materials. A palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) of malonate 4 was utilized as a key transformation to construct the tetrasubstituted chiral center in the target.