121194-48-7Relevant articles and documents
A caveat on the sharpless asymmetric dihydroxylation
Iwashima, Makoto,Kinsho, Takeshi,Smith III, Amos B.
, p. 2199 - 2202 (1995)
Sharpless asymmetric dihydroxylation (AD) of the homochiral synthetic intermediates 2a-c gave anomalous results: pairs of pseudoenantiomeric reagents, expected to generate complementary diastereomer ratios characteristic of double diastereoselection, inst
A concise enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol via Co-catalyzed HKR of anti-(2SR, 3RS)-3-methoxy-3- phenyl-1, 2-epoxypropane
Kiran, I.N. Chaithanya,Reddy, R. Santhosh,Suryavanshi, Gurunath,Sudalai, Arumugam
scheme or table, p. 438 - 440 (2011/03/18)
A short, enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol, cytotoxic styryllactones, has been achieved in high optical purities (99% ee). The strategy employs Co-catalyzed HKR of racemic anti-(2SR, 3RS)-3-methoxy-3-phenyl-1, 2-epoxypropane and Lewis acid-mediated diastereoselective allylation of aldehyde as chiral inducing key reactions.