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121198-78-5

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121198-78-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 121198-78-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,1,9 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 121198-78:
(8*1)+(7*2)+(6*1)+(5*1)+(4*9)+(3*8)+(2*7)+(1*8)=115
115 % 10 = 5
So 121198-78-5 is a valid CAS Registry Number.

121198-78-5Relevant articles and documents

Photoredox Reaction of 2-Mercaptothiazolinium Salts with Silyl Enol Ethers

Zemtsov, Artem A.,Ashirbaev, Salavat S.,Levin, Vitalij V.,Kokorekin, Vladimir A.,Korlyukov, Alexander A.,Dilman, Alexander D.

, (2019/11/29)

A method for the generation of free radicals from thiazolinium salts upon photocatalytic reduction is described. The thiazolinium salts are generated by treatment with methyl triflate of 2-mercaptothiazolines, which can be readily obtained from alkyl bromides and tosylates via a nucleophilic substitution reaction or by hydrothiolation of alkenes. Silyl enol ethers were used to trap the radicals, furnishing ketones after successive single-electron oxidation and elimination of the silyl cation.

Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes

Xu, Guozhang,Gaul, Michael D.,Song, Fengbin,Du, Fuyong,Liang, Yin,DesJarlais, Renee L.,DiLoreto, Karen,Shook, Brian,Rentzeperis, Dennis,Santulli, Rosie,Eckardt, Annette,Demarest, Keith

, (2019/09/12)

Type 2 diabetes mellitus (T2DM) is characterized by chronically elevated plasma glucose levels. The inhibition of glucagon-induced hepatic glucose output via antagonism of the glucagon receptor (GCGR) using a small-molecule antagonist is a promising mecha

INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

-

, (2018/03/25)

The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for e

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