121213-96-5Relevant articles and documents
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)- on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility
Ban, Hitoshi,Muraoka, Masami,Ioriya, Katsuhisa,Ohashi, Naohito
, p. 44 - 48 (2007/10/03)
4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed pote