1212176-33-4

Basic information

• Product Name: (2R)-1-Boc-4-oxopipecolic acid
• Synonyms: (2R)-1-Boc-4-oxopipecolic acid;(R)-1-Boc-4-oxopiperidine-2-carboxylic acid;(2R)-4-Oxo-1,2-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;(R)-1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid;(R)-1-Boc-4-oxopiperidine-2-carboxylic acid 96%;(R)-1-N-Boc-4-oxo-piperidine-2-carboxylic acid
• CAS NO: 1212176-33-4
• Molecular Formula: C11H17NO5
• Molecular Weight: 243.25638
• Mol File: 1212176-33-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 119-124 °C
• Boiling Point: 403.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.257
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.95±0.20(Predicted)
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: (2R)-1-Boc-4-oxopipecolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-Boc-4-oxopipecolic acid(1212176-33-4)
• EPA Substance Registry System: (2R)-1-Boc-4-oxopipecolic acid(1212176-33-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1212176-33-4(Hazardous Substances Data)

Usage

Description

(2R)-1-Boc-4-oxopipecolic acid, also known as (R)-1-Boc-4-oxopiperidine-2-carboxylic acid, is a chiral compound featuring a Boc-protected 4-oxopiperidine-2-carboxylic acid structure. It is characterized by its specific stereochemistry, with the R-configuration at the chiral center, which is crucial for its reactivity and selectivity in chemical reactions.

Uses

Used in Pharmaceutical Industry:
(2R)-1-Boc-4-oxopipecolic acid is used as a key intermediate in the synthesis of various biologically active compounds, specifically targeting the development of EP4 modulators and CDK9 kinase inhibitors. These modulators and inhibitors play a significant role in the treatment of a wide range of diseases, including cancer.
In the synthesis of EP4 modulators:
(2R)-1-Boc-4-oxopipecolic acid is utilized as a reagent for the development of EP4 modulators, which are involved in the regulation of various physiological processes, such as inflammation and pain. By modulating the EP4 receptor, these compounds can potentially offer therapeutic benefits in the treatment of inflammatory and pain-related conditions.
In the synthesis of CDK9 kinase inhibitors:
(2R)-1-Boc-4-oxopipecolic acid is also employed in the production of CDK9 kinase inhibitors, which are crucial in the regulation of cell cycle progression and transcription. Inhibition of CDK9 kinase activity can lead to the suppression of tumor growth and the prevention of cancer progression, making it a valuable target for anticancer drug development.
Overall, (2R)-1-Boc-4-oxopipecolic acid is a versatile reagent with significant applications in the pharmaceutical industry, particularly in the development of therapeutic agents for the treatment of various diseases, including cancer. Its unique structural features and stereochemistry make it an essential component in the synthesis of EP4 modulators and CDK9 kinase inhibitors, contributing to the advancement of novel and effective treatments.