121231-93-4

Basic information

• Product Name: 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine
• Synonyms: 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine
• CAS NO: 121231-93-4
• Molecular Weight: 436.448
• Mol File: 121231-93-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine(121231-93-4)
• EPA Substance Registry System: 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine(121231-93-4)

Safety Data

• Hazardous Substances Data: 121231-93-4(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 2096-10-8 adenosine-2-amine 

Downstream Products

• 121231-95-6 (2R,3R,5R)-5-[2,6-Bis-(trityl-amino)-purin-9-yl]-2-trityloxymethyl-tetrahydro-furan-3-ol 
• 115913-81-0 N²-acetyl-2'-O-tosyl-2,6-diamino-9-β-D-ribofuranosylpurine 
• 115913-76-3 N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine 
• 69370-84-9 2'-O-tosylguanosine 
• 115913-77-4 5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine 
• 115913-75-2 9-(5-O-benzoyl-2-deoxy-β-D-threo-pentofuranosyl)guanine 
• 115913-82-1 5'-O-benzoyl-3'-fluoro-2',3'-dideoxyguanosine 
• 92562-88-4 9-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)guanine 
• 114753-52-5 9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-2,6-diaminopurine 
• 116002-29-0 2,6-diamino-9-(2'-deoxy-β-D-threo-pentafuranosyl)purine 

Relevant articles and documents

Deoxygenative [1,2]-hydride shift rearrangements in nucleoside and sugar chemistry: Analogy with the [1,2]-electron shift in the deoxygenation of ribonucleotides by ribonucleotide reductases

(Chemical Equation Presented) A variant of the semipinacol rearrangement that was observed in our laboratory has been applied to the synthesis of several furanose and pyranose derivatives. The process consists of an "orchestrated" [1,2]-hydride shift with

122. Xylose-DNA containing the four natural bases

Oligonucleotides containing (′-deoxy-β-D-xylofuranosyl)guanine have been prepared. For this purpose 2-aminoadenosine (5) was synthesized and converted to 2′-deoxy-β-D-xyloguanosine (1) The related 2′-deoxy-β-D-xyloisoguanosine (3) and 2′-deoxy-β-D-xyloxan

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.