121253-26-7Relevant articles and documents
Substituent-Directed Alkyl Addition Reactions of Epoxides. 1. Applications to the Synthesis of 3-Hydroxy-4-methylalkanoic Acids
Flippin, Lee A.,Brown, Peter A.,Jalali-Araghi, Keyvan
, p. 3588 - 3596 (2007/10/02)
The addition reactions of 3,4-epoxy-1-alkanol derivatives were studied using Li(CH3)2Cu (ether, 0 deg C) and 2:1 (CH3)3Al-n-BuLi or 2:1 (C2H5)3Al-n-BuLi (hexane, 0 deg C).In all cases Li(CH3)2Cu showed a small (2-3:1) preference for C(4) addition over C(3