121263-19-2 Usage
Description
Calphostin C, also known as CGP049090 or PKF115-584, is a perylenequinone compound isolated from the fungus Cladosporium cladosporioides. It is characterized by its dark red solid appearance and is a potent and specific inhibitor of protein kinase C (PKC), with its inhibition being light-dependent. Calphostin C has the ability to inhibit cell proliferation and induce apoptosis in vitro, making it a valuable compound in various applications.
Uses
Used in Pharmaceutical Industry:
Calphostin C is used as a potent inhibitor of protein kinase C (PKC) for its ability to inhibit cell proliferation and induce apoptosis in tumor cell lines. This makes it a potential candidate for the development of anti-cancer drugs and therapies.
Used in Cancer Research:
Calphostin C is used as an antagonist of Tcf4/b-catenin signaling, which plays a role in the regulation of cell proliferation and survival. By inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines, Calphostin C contributes to the understanding of cancer cell biology and the development of targeted cancer treatments.
Used in Drug Development:
Calphostin C is used as a research tool in the development of novel drug delivery systems and therapeutic strategies. Its light-dependent inhibition of PKC and its effects on cell proliferation and apoptosis make it a valuable compound for studying the mechanisms of cancer cell growth and for designing targeted cancer therapies.
Used in Cellular and Molecular Biology Research:
Calphostin C is used as a specific inhibitor of protein kinase C in cellular and molecular biology research. Its ability to modulate cellular processes and signal transduction pathways makes it a useful tool for studying the roles of PKC in various cellular functions and diseases.
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).
Biochem/physiol Actions
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.
Check Digit Verification of cas no
The CAS Registry Mumber 121263-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,2,6 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 121263-19:
(8*1)+(7*2)+(6*1)+(5*2)+(4*6)+(3*3)+(2*1)+(1*9)=82
82 % 10 = 2
So 121263-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3
