121408-94-4Relevant articles and documents
Enantioselective synthesis of (+)-(2R,3S,6R)-decarestrictine L
Solladie, Guy,Arce, Eva,Bauder, Claude,Carmen Carreno
, p. 2332 - 2337 (2007/10/03)
A convergent enantioselective synthesis of (+)-(2R,3S,6R)- decarestrictine L (1), a natural inhibitor of cholesterol biosynthesis, is described from commercially available (S)-malic acid and (R)-isobutyl lactate. The third chiral center was created by stereoselective reduction of a chiral α-hydroxy ketone, and an intramolecular S(N)2-type reaction allowed the stereocontrolled formation of the tetrahydropyranyl ring.
Labelled Representatives of a Possible Intermediate of Fosfomycin Biosythesis in Streptomyces fradiae: Preparation of (R,S)-(2-Hydroxypropyl)-, (R,S)-, (R)-, (S)-(2-Hydroxypropylpropyl- and (R,S)-(2-Hydroxypropyl)phosphonic acid
Hammerschmidt, Friedrich
, p. 389 - 398 (2007/10/02)
Racemic methyl O-benzyllactate was reduced to the alcohol, transformed into the bromide and reacted with triethylphosphite to give the diethylphosphonate.Removal of protecting groups afforded a phosphonic acid which was purified as its cyclohexylammonium