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1214328-96-7

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1214328-96-7 Usage

General Description

2-Pyridinecarboxylic acid, 3-bromo-6-chloro-, Methyl ester is a chemical compound commonly known as 3-bromo-6-chloropicolinic acid methyl ester. It is a derivative of pyridinecarboxylic acid with a bromine and chlorine substitution at the 3rd and 6th positions, respectively. 2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester is used in various industrial and pharmaceutical applications, including as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. It is also used as a building block in organic synthesis and in research applications. 3-bromo-6-chloropicolinic acid methyl ester is known for its high stability and purity, making it a valuable and versatile chemical for a wide range of applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1214328-96-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,4,3,2 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1214328-96:
(9*1)+(8*2)+(7*1)+(6*4)+(5*3)+(4*2)+(3*8)+(2*9)+(1*6)=127
127 % 10 = 7
So 1214328-96-7 is a valid CAS Registry Number.

1214328-96-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 3-bromo-6-chloropyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names 3-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1214328-96-7 SDS

1214328-96-7Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

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Paragraph 0853; 0854, (2021/03/19)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Discovery of [1,2,4]Triazolo[1,5- a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists

Nakajima, Ryota,Oono, Hiroyuki,Sugiyama, Sakae,Matsueda, Yohei,Ida, Tomohide,Kakuda, Shinji,Hirata, Jun,Baba, Atsushi,Makino, Akito,Matsuyama, Ryo,White, Ryan D.,Wurz, Ryan P.,Shin, Youngsook,Min, Xiaoshan,Guzman-Perez, Angel,Wang, Zhulun,Symons, Antony,Singh, Sanjay K.,Mothe, Srinivasa Reddy,Belyakov, Sergei,Chakrabarti, Anjan,Shuto, Satoshi

supporting information, p. 528 - 534 (2020/03/13)

The retinoic acid receptor-related orphan nuclear receptor γt (RORγt), a promising therapeutic target, is a major transcription factor of genes related to psoriasis pathogenesis such as interleukin (IL)-17A, IL-22, and IL-23R. On the basis of the X-ray cocrystal structure of RORγt with 1a, an analogue of the known piperazine RORγt inverse agonist 1, triazolopyridine derivatives of 1 were designed and synthesized, and analogue 3a was found to be a potent RORγt inverse agonist. Structure-activity relationship studies on 3a, focusing on the treatment of its metabolically unstable cyclopentyl ring and the central piperazine core, led to a novel analogue, namely, 6-methyl-N-(7-methyl-8-(((2S,4S)-2-methyl-1-(4,4,4-trifluoro-3-(trifluoromethyl)butanoyl)piperidin-4-yl)oxy)[1,2,4]triazolo[1,5-a]pyridin-6-yl)nicotinamide (5a), which exhibited strong RORγt inhibitory activity and a favorable pharmacokinetic profile. Moreover, the in vitro and in vivo evaluation of 5a in a human whole-blood assay and a mouse IL-18/23-induced cytokine expression model revealed its robust and dose-dependent inhibitory effect on IL-17A production.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

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Paragraph 0233, (2019/10/15)

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

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