1214361-12-2

Basic information

• Product Name: Methyl 3-chloro-5-(trifluoroMethyl)benzoate
• Synonyms: Methyl 3-chloro-5-(trifluoroMethyl)benzoate;3-Chloro-5-trifluoromethyl-benzoic acid methyl ester
• CAS NO: 1214361-12-2
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.5909496
• Mol File: 1214361-12-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-chloro-5-(trifluoroMethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-chloro-5-(trifluoroMethyl)benzoate(1214361-12-2)
• EPA Substance Registry System: Methyl 3-chloro-5-(trifluoroMethyl)benzoate(1214361-12-2)

Safety Data

• Hazardous Substances Data: 1214361-12-2(Hazardous Substances Data)

Usage

General Description

Methyl 3-chloro-5-(trifluoromethyl)benzoate is an organic compound with the chemical formula C9H6ClF3O2. It is a white crystalline solid that is commonly used in the pharmaceutical and agrochemical industries as an intermediate in the synthesis of various compounds. This chemical is known for its versatile properties, including its high melting point and solubility in organic solvents. It is also used as a building block in the production of insecticides, herbicides, and other agricultural chemicals. Methyl 3-chloro-5-(trifluoromethyl)benzoate is a valuable chemical in organic synthesis and is often used as a reagent in the preparation of complex organic compounds.

Upstream product

• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 22227-63-0 methyl 3-nitro-5-(trifluoromethyl)-benzoate 
• 22235-25-2 3-amino-5-trifluoromethylbenzoic acid methyl ester 
• 53985-49-2 3-chloro-5-(trifluoromethyl)benzoic acid 
• 67-56-1 methanol 
• 886496-83-9 3-chloro-5-trifluoromethylbenzoic acid chloride 

Downstream Products

• 886496-87-3 (3-chloro-5-(trifluoromethyl)phenyl)methanol 
• 477535-43-6 3-chloro-5-(trifluoromethyl)benzaldehyde 
• 1252657-92-3 1-(3-chloro-5-(trifluoromethyl)phenyl)ethanol 
• 1125812-58-9 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one 

Relevant articles and documents

Trifluoromethylation of Arylsilanes with [(phen)CuCF3]

A method for the trifluoromethylation of arylsilanes is reported. The reaction proceeds with [(phen)CuCF3] as the CF3source under mild, oxidative conditions with high functional-group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C?H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C?H bond into a C?CF3bond in active pharmaceutical ingredients which do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation.

DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES

The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.