1214886-35-7 Usage
Description
27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide is a complex organic compound belonging to the class of naturally occurring withanolides, a group of steroids found in plants of the Solanaceae family, such as Withania somnifera (Ashwagandha). This specific witha-2,24-dienolide features a unique structure with a 6-membered lactone ring and multiple functional groups, including acetoxy, epoxy, hydroxy, and oxo groups. Its potential pharmacological and medicinal properties, such as anti-inflammatory, antioxidant, and neuroprotective effects, make it a compound of interest for therapeutic applications.
Used in Pharmaceutical Industry:
27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide is used as a pharmaceutical agent for its potential therapeutic applications due to its anti-inflammatory, antioxidant, and neuroprotective effects. These properties make it a promising candidate for the development of treatments targeting various health conditions and diseases.
Used in Nutraceutical Industry:
In the nutraceutical industry, 27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide is used as a dietary supplement ingredient for its health-promoting properties. Its potential to support anti-inflammatory, antioxidant, and neuroprotective functions can contribute to overall wellness and may be beneficial for maintaining cognitive health and reducing oxidative stress.
Used in Cosmetic Industry:
27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide is used as an active ingredient in cosmetic products for its potential skin health benefits. 27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide's antioxidant and anti-inflammatory properties may help protect the skin from environmental stressors, promote skin regeneration, and support a youthful appearance.
Used in Research and Development:
In the field of research and development, 27-acetoxy-5β,6β-epoxy-4β-hydroxy-1-oxo-witha-2,24-dienolide serves as a subject of study for its potential applications in medicine and healthcare. Scientists and researchers investigate its pharmacological properties to better understand its mechanisms of action and to explore new ways to harness its benefits for therapeutic purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 1214886-35-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,4,8,8 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1214886-35:
(9*1)+(8*2)+(7*1)+(6*4)+(5*8)+(4*8)+(3*6)+(2*3)+(1*5)=157
157 % 10 = 7
So 1214886-35-7 is a valid CAS Registry Number.
1214886-35-7Relevant articles and documents
Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers
Llanos, Gabriel G.,Araujo, Liliana M.,Jiménez, Ignacio A.,Moujir, Laila M.,Rodríguez, Jaime,Jiménez, Carlos,Bazzocchi, Isabel L.
, p. 52 - 64 (2017)
Apoptosis inducers represent an attractive approach for the discovery and development of anticancer agents. Herein, we report on the development by molecular fine tuning of a withaferin A-based library of 63 compounds (2–64), 53 of them reported for the first time. Their antiproliferative evaluation on HeLa, A-549 and MCF-7 human tumor cell lines identified fifteen analogues displaying higher activity (IC50 values ranging 0.3–4.8 μM) than the lead (IC50 values ranging 1.3–10.1 μM) either in lag or log growth phases. SAR analysis revealed that acylation enhances cytotoxicity, suggesting the hydrophobic moiety contributes to the activity, presumably by increasing affinity and/or cell membrane permeability. Further investigation clearly indicated that compounds 3, 11, 12, and 18 induce apoptosis evidenced by chromatin condensation, phosphatidylserine externalization, and caspase-3 activation effects on HeLa cells. The potent capacity to induce apoptosis with concomitant cell loss in G2/M highlights the potential of 27-benzyl analogue (18) as an apoptotic inducer drug candidate.
WITHAFERIN A ANALOGS AND USES THEREOF
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Page/Page column 76, (2010/04/06)
The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.
