121497-09-4

Basic information

• Product Name: 4-(4-[1,3]Dioxolan-2-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
• Synonyms: 4-(4-[1,3]Dioxolan-2-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
• CAS NO: 121497-09-4
• Molecular Weight: 373.406
• Mol File: 121497-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-[1,3]Dioxolan-2-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-[1,3]Dioxolan-2-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester(121497-09-4)
• EPA Substance Registry System: 4-(4-[1,3]Dioxolan-2-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester(121497-09-4)

Safety Data

• Hazardous Substances Data: 121497-09-4(Hazardous Substances Data)

Upstream product

• 40681-88-7 4-(1,3-dioxolan-2-yl)benzaldehyde 
• 14205-39-1 methyl 3-aminocrotonate 

Downstream Products

• 121497-14-1 dimethyl 4-(4-formylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Syntheses and bioevaluation of substituted dihydropyridines for pregnancy-interceptive activity in hamsters

A number of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-substituted-1,4-dihydropyridines were synthesized and evaluated for pregnancy-interceptive activity in mated hamsters. Our of 24 compounds, 12, 15, 21, 22, 28, and 34 caused a marked reduction in the number of implantations when administered on days 3-8 postcoitum. In an in vitro competition assay, none of the compounds exhibited noticeable binding affinity for uterine progesterone receptors. The results reported here have helped to identify new leads for developing pregnancy-interceptive agents and the active compounds do not seem to elicit their interceptive effect through receptor-mediated inhibition of progesterone action in hamster uterus.