1215018-92-0

Basic information

• Product Name: N-(3-(3-methylphenyl)-butyryl)-8-aminoquinoline
• Synonyms: N-(3-(3-methylphenyl)-butyryl)-8-aminoquinoline
• CAS NO: 1215018-92-0
• Molecular Weight: 304.392
• Mol File: 1215018-92-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(3-(3-methylphenyl)-butyryl)-8-aminoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(3-methylphenyl)-butyryl)-8-aminoquinoline(1215018-92-0)
• EPA Substance Registry System: N-(3-(3-methylphenyl)-butyryl)-8-aminoquinoline(1215018-92-0)

Safety Data

• Hazardous Substances Data: 1215018-92-0(Hazardous Substances Data)

Upstream product

• 1416276-98-6 bis(3-methylphenyl)iodonium trifluoromethanesulfonate 
• 33757-47-0 N-(quinolin-8-yl)butyramide 
• 19169-97-2 m-(diacetoxyiodo)toluene 
• 106-31-0 butanoic acid anhydride 
• 578-66-5 8-amino quinoline 
• 625-95-6 3-Iodotoluene 
• 141-75-3 butyryl chloride 

Downstream Products

• 19355-29-4 (+/-)-3-(3-methylphenyl)butanoic acid 

Relevant articles and documents

One-pot, solvent-free Pd(II)-catalyzed direct β-C-H arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group

A one-pot, multicomponent-type, solvent-free Pd(II)-catalyzed direct β-C-H activation/arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group (DG) is reported. Typically, the DG-assisted β-C-H activation/ar

Palladium-catalyzed Cs2CO3-promoted arylation of unactivated C(sp3)-H bonds by (diacetoxyiodo)arenes: Shifting the reactivity of (diacetoxyiodo)arenes from acetoxylation to arylation

PdCl2(CH3CN)2-catalyzed arylation of unactivated C(sp3)-H bonds using (diacetoxyiodo)arenes as arylation reagents is reported. The reactivity of (diacetoxyiodo)arenes as arylation reagents is enabled in the presence of Cs2CO3 under the reaction conditions. This arylation method is highly efficient and occurs without the use of silver salt. The reaction tolerates a broad substrate scope that was not demonstrated by other silver salt-free C(sp3)-H bond arylation conditions. The synthetic utility of the method is further illustrated in the synthesis of the psychotropic drug phenibut. A detailed mechanism study has been conducted to understand the reaction pathway.