1215290-52-0

Basic information

• Product Name: N-((8-hydroxyquinolin-5-yl)methyl)-4-methylbenzamide
• Synonyms: N-((8-hydroxyquinolin-5-yl)methyl)-4-methylbenzamide
• CAS NO: 1215290-52-0
• Molecular Weight: 292.337
• Mol File: 1215290-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((8-hydroxyquinolin-5-yl)methyl)-4-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((8-hydroxyquinolin-5-yl)methyl)-4-methylbenzamide(1215290-52-0)
• EPA Substance Registry System: N-((8-hydroxyquinolin-5-yl)methyl)-4-methylbenzamide(1215290-52-0)

Safety Data

• Hazardous Substances Data: 1215290-52-0(Hazardous Substances Data)

Upstream product

• 81748-72-3 5-(aminomethyl)-8-hydroxyquinoline 
• 874-60-2 4-methyl-benzoyl chloride 

Relevant articles and documents

Structure-activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines

A series of twenty six 8-hydroxyquinoline substituted amines, structurally related to compounds 2 and 3, were synthesized to evaluate the effects of structural changes on antitumor activity and understand their mechanism of action. The studies were performed on a wide variety of cancer cell lines within glioma and carcinoma models. The results obtained from chemical models and biological techniques such as microarrays suggest the following hypothesis that a quinone methide intermediate which does not react with DNA but which gives covalent protein thiol adducts. Micro-array analysis showed that the drugs induce the expression of a variety of stress related genes responsible for the cytotoxic and cytostatic effects in carcinoma and glioblastoma cells respectively. The described analogues could represent new promising anti-cancer candidates with specific action mechanisms, targeting accessible thiols from specific proteins and inducing potent anti-cancer effects.