1215325-46-4

Basic information

• Product Name: ethyl 4((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carboxylate
• Synonyms: ethyl 4((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carboxylate
• CAS NO: 1215325-46-4
• Molecular Weight: 505.561
• Mol File: 1215325-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carboxylate(1215325-46-4)
• EPA Substance Registry System: ethyl 4((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carboxylate(1215325-46-4)

Safety Data

• Hazardous Substances Data: 1215325-46-4(Hazardous Substances Data)

Upstream product

• 870812-31-0 (3R)-3-amino-N,N-dimethyl-4-(phenylthio)butanamide 
• 31602-11-6 ethyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylate 

Downstream Products

• 1215325-49-7 4-((R)-1-(dimethylcarbamoyl)-3-(phenylthio)propan-2-ylamino)-8-(trifluoromethyl)quinoline-3-carbohydrazide 

Relevant articles and documents

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.