1215667-16-5

Basic information

• Product Name: N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4- Dioxane coMplex
• Synonyms: N-[[N-[(SucciniMidooxy)carbonyl]-β-alanyl]oxy]succiniMide 1,4- Dioxane
• CAS NO: 1215667-16-5
• Molecular Formula: C16H21N3O10
• Molecular Weight: 415.35204
• Product Categories: Cross Linking Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1215667-16-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 163-164°C
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4- Dioxane coMplex(CAS DataBase Reference)
• NIST Chemistry Reference: N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4- Dioxane coMplex(1215667-16-5)
• EPA Substance Registry System: N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4- Dioxane coMplex(1215667-16-5)

Safety Data

• Hazardous Substances Data: 1215667-16-5(Hazardous Substances Data)

Usage

Description

N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4Dioxane coMplex is a short, amino reactive homobifunctional crosslinking reagent with a crosslinking distance of 8.3 ?. It is a white solid that is useful in polymer coupling to proteins, as it may lead to better selectivity among all the amino groups present in a protein. This results in less heterogeneous PEG-protein conjugates mixtures because only the most nucleophilic and solvent-exposed amines can react.

Uses

Used in Pharmaceutical Industry:
N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4Dioxane coMplex is used as a crosslinking reagent for enhancing the selectivity of polymer coupling to proteins. This is particularly useful in the development of PEG-protein conjugates, as it allows for the formation of less heterogeneous mixtures by targeting only the most nucleophilic and solvent-exposed amines.
Used in Bioconjugation:
N-SucciniMidoxycarbonyl--alanine N-SucciniMidyl Ester 1,4Dioxane coMplex is used as a homobifunctional crosslinking reagent in bioconjugation processes. Its short length and amino reactivity make it suitable for creating stable and specific linkages between proteins and other biomolecules, which is essential for various research and diagnostic applications.