121638-08-2

Basic information

• Product Name: 2,8-Bis<(N-carbonyl-Gly-Phe-NMe2)-Pro-D-Ala-NH>epindolidione
• CAS NO: 121638-08-2
• Molecular Weight: 1179.3
• Mol File: 121638-08-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,8-Bis<(N-carbonyl-Gly-Phe-NMe2)-Pro-D-Ala-NH>epindolidione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-Bis<(N-carbonyl-Gly-Phe-NMe2)-Pro-D-Ala-NH>epindolidione(121638-08-2)
• EPA Substance Registry System: 2,8-Bis<(N-carbonyl-Gly-Phe-NMe2)-Pro-D-Ala-NH>epindolidione(121638-08-2)

Safety Data

• Hazardous Substances Data: 121638-08-2(Hazardous Substances Data)

Upstream product

• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 50903-52-1 (tert-butoxycarbonyl)-L-proline pentafluorophenol ester 
• 105500-29-6 N²-(benzyloxycarbonyl)-N¹,N¹-dimethyl-L-phenylalanin-amid 
• 1161-13-3 N-Cbz-L-Phe 
• 121638-09-3 2,8-Bis<(N-carbonyl-Gly-OEt)-Pro-D-Ala-NH>epindolidione 
• 121616-44-2 2,8-Bis(Boc-Pro-D-Ala-NH)epindolidione 
• 121616-43-1 2,8-bis(Boc-D-Ala-NH)epindolidione 
• 128302-65-8 dimethyl bis(p-nitroanilino)maleate 
• 121616-41-9 2-(methoxycarbonyl)-3-(p-nitroaniline)-6-nitro-4-quinolone 
• 104347-81-1 L-Phenylalanine Dimethylamide Hydrobromide 
• 121616-45-3 2,8-Bis<(N-carbonyl-Gly-OH)-Pro-D-Ala-NH>epindolidione 

Relevant articles and documents

Synthesis and Conformational Analysis of Epindolidione-Derived Peptide Models for β-Sheet Formation

Synthesis of 2,8-diaminoepindolidione (2,8-diaminodibenzonaphthyridine-6,12(5,11H)-dione) in 19percent yield from p-nitroaniline is reported, as well as further conversion to 2,8-bis(Boc-L-Pro-Xxx)epindolidione (Xxx=Gly, D-Ala) and then to 2,8-bis(OC(Yyy-Zzz-NMe2)-L-Pro-Xxx)epindolidione (Yyy=Gly, L-Ala, D-Ala; Zzz=Gly, L-Phe, D-Phe).The β-turn-forming tendencies of the series 2,8-bis(X-L-Pro-D-Ala)epindolidione, where X=Ac, Boc, and COGlyOEt, are assigned from 1H NMR evidence.