121643-44-5

Basic information

• Product Name: 2-Methoxy-3-(trifluoromethyl)pyridine
• Synonyms: BUTTPARK 45\01-90;2-Methoxy-3-(trifluoromethyl)pyridine 98%;2-Methoxy-3-(trifluoromethyl)pyridine98%;METHOXY-3-TRIFLUOROMETHYLPYRIDINE;3-(trifluoroMethyl)-2-Methoxypyridine;2-METHOXY-3-(TRIFLUOROMETHYL)PYRIDINE
• CAS NO: 121643-44-5
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.12
• Product Categories: Pyridines;Pyridine;C7 and C8;Heterocyclic Building Blocks
• Mol File: 121643-44-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 44 °C
• Flash Point: 118 °F
• Appearance: Light yellow liquid
• Density: 1.297 g/mL at 25 °C
• Refractive Index: n20/D 1.441
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 0.97±0.10(Predicted)
• CAS DataBase Reference: 2-Methoxy-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-3-(trifluoromethyl)pyridine(121643-44-5)
• EPA Substance Registry System: 2-Methoxy-3-(trifluoromethyl)pyridine(121643-44-5)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 10-25-36/37/38-20/21/22
• Safety Statements: 16-26-45-36
• RIDADR: UN 1992 3/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 121643-44-5(Hazardous Substances Data)

Usage

Description

2-Methoxy-3-(trifluoromethyl)pyridine is a pyridine derivative characterized by the presence of a methoxy group at the 2nd position and a trifluoromethyl group at the 3rd position on the pyridine ring. 2-Methoxy-3-(trifluoromethyl)pyridine is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
2-Methoxy-3-(trifluoromethyl)pyridine is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to serve as a building block in the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Methoxy-3-(trifluoromethyl)pyridine is utilized as a key component in the design and synthesis of novel drug candidates. Its presence in a molecule can influence the pharmacokinetic and pharmacodynamic properties of the drug, making it a valuable tool in the development of new therapeutic agents.
Used in Chemical Research:
2-Methoxy-3-(trifluoromethyl)pyridine is also employed in chemical research as a model compound to study the reactivity and properties of pyridine derivatives. This helps researchers understand the behavior of similar compounds and develop new synthetic strategies for the preparation of complex molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

storage

2-Methoxy-3-(trifluoromethyl)pyridine store at room temperature.

Upstream product

• 67-56-1 methanol 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 124-41-4 sodium methylate 
• 2926-29-6 Langlois reagent 
• 163105-90-6 2-methoxypyridin-3-yl-boronic acid 
• 112197-15-6 3-iodo-2-methoxypyridine 
• 1628-89-3 2-methoxypyridine 
• 2926-30-9 sodium triflate 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1354690-24-6 1-[(3S)-3-({5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]pyrido[4,3-d]pyrimidin-4-yl}amino)pyrrolidin-1-yl]propan-1-one 
• 1354691-99-8 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one hippurate 
• 1214377-42-0 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine 
• 1354690-31-5 ((S)-3-(6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ylamino)pyrrolidin-1-yl)((1R,4R)-4-methoxycyclohexyl)methanone 
• 1354690-30-4 ((S)-3-(6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ylamino)pyrrolidin-1-yl)((1S,4S)-4-methoxycyclohexyl)methanone 
• 1211532-15-8 6-methoxy-5-(trifluoromethyl)nicotinic acid 

Relevant articles and documents

Copper-mediated trifluoromethylation of aryl-, heteroaryl-, and vinyltrifluoroborates with Langlois' reagent

An effortless and realistic procedure for the copper-mediated trifluoromethylation of aryl-, heteroaryl- and vinyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is presented. The developed method produces trifluoromethyl arenes and -alkenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.

Metal- and oxidant-free photoinduced aromatic trifluoromethylation performed in aerated gel media: Determining the effects on yield and selectivity

In this work we have investigated the potential benefits of using supramolecular gel networks as reaction media to carry out air-sensitive metal-free light-induced trifluoromethylation of six-membered (hetero)arenes under aerobic conditions. This reaction was performed at room temperature (RT) using sodium triflinate (CF3SO2Na, Langlois' reagent) as a source of radicals and diacetyl as electron donor. The effects of confinement in gel media, concentration of reactants, and type of light source on yield and product distribution were evaluated and compared to the results obtained in homogeneous solution. Four different low molecular weight (LMW) gelators were employed in this study. The results confirmed the blocking effect of the gel medium against reaction quenching by external oxygen, as well as a certain control on the kinetics and selectivity.

Use of Inhibitors of the Activity or Function of PI3K

The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.