121661-49-2

Basic information

• Product Name: 2-(2-Diethylamino-ethyl)-5-phenyl-5,6,7,8-tetrahydro-2H-pyrrolo[4,3,2-de]cinnolin-3-one
• CAS NO: 121661-49-2
• Molecular Weight: 350.464
• Mol File: 121661-49-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-Diethylamino-ethyl)-5-phenyl-5,6,7,8-tetrahydro-2H-pyrrolo[4,3,2-de]cinnolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Diethylamino-ethyl)-5-phenyl-5,6,7,8-tetrahydro-2H-pyrrolo[4,3,2-de]cinnolin-3-one(121661-49-2)
• EPA Substance Registry System: 2-(2-Diethylamino-ethyl)-5-phenyl-5,6,7,8-tetrahydro-2H-pyrrolo[4,3,2-de]cinnolin-3-one(121661-49-2)

Safety Data

• Hazardous Substances Data: 121661-49-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 56671-28-4 4,5,6,7-tetrahydro-4-oxobenzofuran-3-carboxylic acid 
• 924-29-8 N-[2-(diethylamino)ethyl]hydrazine 
• 121626-39-9 4-oxo-1-phenyl-4,5,6,7-tetrahydroindole-3-carboxylic acid 

Relevant articles and documents

Synthesis and Oral Hypoglycemic Properties of 4-Oxo-4,5,6,7-tetrahydroindole-3-acetic Acids

Condensation of β-acetyl-2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexene-1-propionic acid (8, R =R1 =Me) with ammonium acetate and primary amines affords tetrahydroindole-3-acetic acids (9), while another dimedone derivative 13 serves as starting material for isomeric indole-2-acetic acids (15). 4-Oxotetrahydroindole-2-carboxylic acids (77, 78) and 3-carboxylic acids (85, 86) are obtained from the corresponding benzofurans.Some of the 3-carboxylic acid esters are transformed to tricyclic compounds like 21-25.Good oral hypoglycemic activity in normal rats is shown generally by the 3-acetic acids among which C 8778-GO (3) and C 9001-GO (4) are most active.These two acids are also active in streptozotocin-induced diabetic rats and have been investigated extensively.Structure-activity relationships are discussed.