1216659-29-8

Basic information

• Product Name: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride
• Synonyms: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride
• CAS NO: 1216659-29-8
• Molecular Formula: C16H16Cl2N6O3
• Molecular Weight: 411.24264
• Mol File: 1216659-29-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride(1216659-29-8)
• EPA Substance Registry System: 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride(1216659-29-8)

Safety Data

• Hazardous Substances Data: 1216659-29-8(Hazardous Substances Data)

Usage

Uses

A metabolite of Zopiclone (Z700500).

Upstream product

• 138729-47-2 eszopiclone 

Relevant articles and documents

Synthesis of enantiomerically pure desmethylzopiclone and determination of its absolute configuration

Two synthetic methods have been established for the preparation of enantiomerically pure desmethylzopiclone, a metabolite of zopiclone. In Method A, (S)-desmethylzopiclone was prepared by demethylation of (S)-zopiclone with 1-chloroethyl chloroformate in high yield. Enantiomerically pure zopiclone (>99% ee) was obtained through a highly efficient resolution process in >36% overall yield. In Method B, racemic desmethylzopiclone was resolved with L-N-benzyloxycarbonyl phenylalanine (L-ZPA) followed by recrystallization in good yield. The absolute stereochemistry of the (+)-enantiomer was first determined to be the (S)-configuration by X-ray crystallography.