121716-27-6

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 5-amino-3-methyl-1-phenyl-, ethyl ester
• CAS NO: 121716-27-6
• Molecular Formula: C13H15N3O2
• Molecular Weight: 245.281
• Mol File: 121716-27-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 5-amino-3-methyl-1-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 5-amino-3-methyl-1-phenyl-, ethyl ester(121716-27-6)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 5-amino-3-methyl-1-phenyl-, ethyl ester(121716-27-6)

Safety Data

• Hazardous Substances Data: 121716-27-6(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 35260-93-6 ethyl 2-cyano-3-ethoxybut-2-enoate 
• 59-88-1 phenylhydrazine hydrochloride 
• 105-56-6 ethyl 2-cyanoacetate 
• 634-55-9 ethyl 2-cyanoacetoacetate 
• 217201-53-1 2-Mercapto-5-methyl-7phenylpyrazolo[3,4-d]-1,3,2-diazaphosphorin-2,4(1H,3H)-dithione 
• 217201-82-6 2,4-Dimethylthio-5-methyl-7phenylpyrazolo[3,4-d]-1,3,2-diazaphosphorin-2(1H)-thione 
• 64-17-5 ethanol 
• 217201-71-3 5-Amino-3-methyl-7-methoxythiocarbonyl-1-phenylpyrazole 

Downstream Products

• 947238-81-5 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbohydrazide 
• 50427-81-1 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid amide 

Relevant articles and documents

Metal-free ring opening of 5-amino-1,4-diaryl-1H-pyrazoles: A facile access to 2-aryl-3-arylazoacrylonitriles

Various 2-aryl-3-arylazoacrylonitriles are synthesized while attempting the intramolecular N-arylation of 5-aminopyrazoles, using the hypervalent iodine reagent. The synthesis involves phenyl iodine diacetate-assisted ring opening of 5-aminopyrazoles at r

Synthesis of pyrazolopyrimidinones as sildenafil derivatives and sclerotigenin

A series of novel pyrazolo pyrimidinone derivatives (3(a–d), 4(a–d), and 6(a–d)) was synthesized from various pyrazolo amides (2a–d) which are synthesized by the reaction between ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) and various lithium amides. In addition, we also described the synthesis of sclerotigenin drug molecule which has quinazoline moiety from simple 2-nitro benzoic acid with high yields.

A convenient microwave-assisted propylphosphonic anhydride (T3P mediated one-pot pyrazolone synthesis

This paper describes a facile, efficient, and clean synthesis of various pyrazolones by employing T3P as a catalyst and performing the reaction under microwave irradiation. This two-step, one-pot reaction proceeded readily and tolerated a variety of functional groups. A wide range of pyrazolone derivatives were obtained in good to excellent yields. A one-pot, two-step procedure for the synthesis of pyrazolones is presented. This method, which uses T3P and microwave irradiation, is particularly easy to carry out and offers a notable alternative to the strongly acidic conditions that are generally employed with other synthetic approaches. Copyright