1217314-90-3 Usage
Description
4-(1H-Benzimidazol-2-yl)-3-(2,4-dihydroxyphenyl)-1H-pyrazole-5-propanoic Acid is a novel compound with a unique chemical structure that features a benzimidazole and a pyrazole ring, along with a dihydroxyphenyl group. 4-(1H-BenziMidazol-2-yl)-3-(2,4-dihydroxyphenyl)-1H-pyrazole-5-propanoic Acid has demonstrated significant biological activity, particularly as an inhibitor of DNA gyrase B, which plays a crucial role in bacterial DNA replication, transcription, and repair.
Uses
Used in Pharmaceutical Industry:
4-(1H-Benzimidazol-2-yl)-3-(2,4-dihydroxyphenyl)-1H-pyrazole-5-propanoic Acid is used as an antimicrobial agent for its low micromolar antigyrase activity. It targets DNA gyrase B, an essential enzyme in bacterial DNA metabolism, thereby inhibiting bacterial growth and potentially serving as a novel therapeutic option for treating bacterial infections.
Used in Research and Development:
In the field of research and development, 4-(1H-Benzimidazol-2-yl)-3-(2,4-dihydroxyphenyl)-1H-pyrazole-5-propanoic Acid can be utilized as a starting point for the design and synthesis of new inhibitors targeting DNA gyrase B. This may lead to the development of more effective antibiotics or other therapeutic agents against bacterial infections.
Used in Drug Discovery:
4-(1H-Benzimidazol-2-yl)-3-(2,4-dihydroxyphenyl)-1H-pyrazole-5-propanoic Acid is used as a lead compound in drug discovery for its potential to be optimized and developed into a more potent and selective inhibitor of DNA gyrase B. This could result in the creation of new drugs with improved efficacy and reduced side effects for the treatment of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 1217314-90-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,3,1 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1217314-90:
(9*1)+(8*2)+(7*1)+(6*7)+(5*3)+(4*1)+(3*4)+(2*9)+(1*0)=123
123 % 10 = 3
So 1217314-90-3 is a valid CAS Registry Number.
1217314-90-3Relevant articles and documents
Cyclic carboxylic anhydrides as new reagents for formation of chromone ring
Frasinyuk, Mykhaylo S.,Bondarenko, Svitlana P.,Gorbulenko, Nataliia V.,Turov, Alexander V.,Khilya, Volodymyr P.
, p. 768 - 774 (2014/06/10)
The propensity of cyclic carboxylic anhydrides to undergo ring-opening was exploited in a reaction with 2'-hydroxy-α-heteroarylacetophenones leading to the formation of chromones. New simple method was developed for the synthesis of 2-(ω-carboxyalkyl)-3-h
