121751-70-0

Basic information

• Product Name: 1-phenoxycarbonyl-2-oxopyrrolidine
• Synonyms: 1-phenoxycarbonyl-2-oxopyrrolidine
• CAS NO: 121751-70-0
• Molecular Weight: 205.213
• Mol File: 121751-70-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-phenoxycarbonyl-2-oxopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenoxycarbonyl-2-oxopyrrolidine(121751-70-0)
• EPA Substance Registry System: 1-phenoxycarbonyl-2-oxopyrrolidine(121751-70-0)

Safety Data

• Hazardous Substances Data: 121751-70-0(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 1885-14-9 phenyl chloroformate 
• 1174302-48-7 1-{[(4-methylphenyl)sulfonyl]oxy}piperidine-2,6-dione 
• 108-95-2 phenol 
• 55379-71-0 phenyl pyrrolidine-1-carboxylate 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 

Relevant articles and documents

Studies on the Lossen-type rearrangement of N-(3-phenylpropionyloxy) phthalimide and N-tosyloxy derivatives with several nucleophiles

The reaction of N-(3-phenylpropionyloxy)phthalimide (1a) and N-tosyloxy (5a,b) derivatives with nucleophiles was examined and found to give the products via Lossen-type rearrangement. In order to obtain the scope of this reaction mechanism, further studies the reaction of several N-sulfonyloxyimide derivatives with various nucleophiles under similar conditions were carried out and found to afford the corresponding same types of products in high yields.

Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid

Oxidative carbon-carbon bond cleavage of N-alkoxycarbonylated cyclic amines was accomplished by NaNO2 in TFA to afford ω-amino carboxylic acid in high yield. Optically active 3-hydroxypiperidine derivatives and 3-pipecolinate were converted to

Carbamoylpyrolidone derivatives and drugs for senile dementia

A compound of the formula: STR1 (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, STR2 one of A and B is STR3 and the other is >CH2 : R1 is hydrogen or C1 -C5 alkyl; Z1 is phenyl, benzyl, or isoxazolyl each optionally substituted by a halogen, methoxy, or methyl group; Z2 is hydrogen, C1 -C5 alkyl, C2 -C5 alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z1 and Z2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z3 is C1 -C5 hydroxyalkyl, di(C1 -C5 alkyl)sulfamoyl, 6-membered heterocyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z5 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z6 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3) or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.