1217630-38-0

Basic information

• Product Name: (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
• Synonyms: (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE;(S)-2-(2,5-Difluorophenyl)pyrrolidine
• CAS NO: 1217630-38-0
• Molecular Formula: C10H11F2N
• Molecular Weight: 183.2
• Mol File: 1217630-38-0.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 213.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.02±0.10(Predicted)
• CAS DataBase Reference: (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE(1217630-38-0)
• EPA Substance Registry System: (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE(1217630-38-0)

Safety Data

• Hazardous Substances Data: 1217630-38-0(Hazardous Substances Data)

Usage

General Description

"(2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE" is a chemical compound that belongs to the class of organic compounds known as aryl fluorides. These are aromatic compounds containing a fluorine atom linked to an aromatic group. It specifically has a Pyrrolidine ring structure, a common feature in many natural products, including alkaloids and antibiotics. The "2S" denotes the specific arrangement or orientation of atoms within the molecule. (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE has the presence of two fluorine atoms on its phenyl ring, at the 2nd and 5th positions. Its characteristics and properties may vary depending upon its reactive groups, but detailed specifics about its uses and other properties are not widely documented or well-known.

Upstream product

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Relevant articles and documents

Efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine via a recycle process of resolution

An efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine ((R)-1) from the racemate based on a recycle process of resolution/racemization was described. In the process, the desired (R)-1 was obtained by resolution with D-malic acid in 95% EtOH. Me

METHODS FOR PREPARING TYROSINE RECEPTOR KINASE INHIBITORS

The present disclosure relates to pyrazolo[1,5-α]pyrimidine compounds useful as TRK inhibitors and compounds useful in preparing pyrazolo[1,5-α]pyrimidine compounds, and methods of making and using same. This abstract is intended as a scanning tool for pu

Synthesis method of (R)-2-(2, 5-difluorophenyl) pyrrolidine

The invention belongs to the technical field of chemical pharmacy, and relates to a synthetic method of (R)-2-(2, 5-difluorophenyl)pyrrolidine. The synthesis method comprises the following steps: (1) carrying out dehydration condensation reaction on a compound as shown in a formula 1 and a chiral induction reagent (R) tert-butylsulfinamide to obtain a compound as shown in a formula 2; (2) carrying out addition reaction on the compound in the formula 2 and a Grignard reagent to obtain a compound in a formula 3; (3) carrying out a reduction/cyclization reaction on the compound shown in the formula 3, trifluoroacetic acid and triethylsilane to obtain a compound shown in a formula 4; (4) splitting the compound shown in the formula 4 by (D)-malic acid to obtain the (R)-2-(2, 5-difluorophenyl) pyrrolidine*D malate compound with EE being greater than 98% shown in the formula 5; and (5) dissociating the compound in the formula 5 with a sodium hydroxide solution to obtain (R)-2-(2, 5-difluorophenyl) pyrrolidine. By utilizing the synthetic method of (R)-2-(2,5-difluorophenyl)pyrrolidine, the cost is low, the optical purity is high, the subsequent separation process is simplified, the raw materials are easy to obtain, the process conditions are mild, and the synthetic method is suitable for synthesizing (R)-2-(2, 5-difluorophenyl) pyrrolidine in large-scale production.