1217664-77-1 Usage
Description
(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile, also known as 2-Isopropyl-5-methylcyclohexane-1-carbonitrile, is a chiral compound with a molecular formula of C10H17N. It is a colorless liquid that features a unique structure and stereochemistry, denoted as (1R,2R,5R). (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile is highly valued for its role as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries.
Uses
Used in Pharmaceutical Industry:
(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique structure allows for the creation of molecules with targeted actions and improved efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile serves as a key intermediate in the production of agrochemicals, aiding in the development of effective pesticides and other agricultural chemicals that can protect crops and enhance yield.
Used in Fragrance and Flavor Industry:
(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile is also utilized as a component in fragrances and flavors, capitalizing on its unique chemical properties to create distinct scents and tastes for various consumer products.
Used in Organic Chemistry Research and Development:
(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile's distinctive structure and properties make (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile a valuable target molecule for research and development in organic chemistry. It is instrumental in advancing scientific understanding and facilitating the discovery of innovative applications in diverse fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1217664-77-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,6,6 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1217664-77:
(9*1)+(8*2)+(7*1)+(6*7)+(5*6)+(4*6)+(3*4)+(2*7)+(1*7)=161
161 % 10 = 1
So 1217664-77-1 is a valid CAS Registry Number.
1217664-77-1Relevant articles and documents
Synthesis, characterization and hplc analysis of the (1S,2S,5R)-diastereomer and the enantiomer of the clinical candidate ar-15512
Abás, Sònia,Escolano, Carmen,Galdeano, Carles,Pujol, Eugènia,Rodríguez-Arévalo, Sergio,Vázquez, Santiago
, (2021/06/12)
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and absolute configuration, (1R,2S,5R), have been previously solved by cryo-electron microscopy. The route of synthesis of AR-15512 has also been reported, revealing that epimerization processes at the C-1 can occur at specific stages of the synthesis. In order to confirm that the desired configuration of AR-15512 does not change throughout the process and to discard the presence of the enantiomer in the final product due to possible contamination of the initial starting material, both the enantiomer of AR-15512 and the diastereomer at the C-1 were synthesized and fully characterized. In addition, the absolute configuration of the (1S,2S,5R)-diastereomer was determined by X-ray crystallographic analysis, and new HPLC methods were designed and developed for the identification of the two stereoisomers and their comparison with the clinical candidate AR-15512.
Triiodide-Mediated δ-Amination of Secondary C?H Bonds
Wappes, Ethan A.,Fosu, Stacy C.,Chopko, Trevor C.,Nagib, David A.
, p. 9974 - 9978 (2016/08/16)
The Cδ?H amination of unactivated, secondary C?H bonds to form a broad range of functionalized pyrrolidines has been developed by a triiodide (I3?)-mediated strategy. By in situ 1) oxidation of sodium iodide and 2) sequestration of the transiently generated iodine (I2) as I3?, this approach precludes undesired I2-mediated decomposition which can otherwise limit synthetic utility to only weak C(sp3)?H bonds. The mechanism of this triiodide-mediated cyclization of unbiased, secondary C(sp3)?H bonds, by either thermal or photolytic initiation, is supported by NMR and UV/Vis data, as well as intercepted intermediates.
Syntheses of c-l axial derivatives of l-menthol
Dillner, Debra K.
experimental part, p. 147 - 152 (2009/12/24)
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