1217831-54-3

Basic information

• Product Name: (R)-2-(4-CHLOROPHENYL)PYRROLIDINE
• Synonyms: (R)-2-(4-CHLOROPHENYL)PYRROLIDINE;(2R)-2-(4-chlorophenyl)pyrrolidine
• CAS NO: 1217831-54-3
• Molecular Formula: C₁₀H₁₂ClN
• Molecular Weight: 181.66
• Mol File: 1217831-54-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 269℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.129
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.58±0.10(Predicted)
• CAS DataBase Reference: (R)-2-(4-CHLOROPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-CHLOROPHENYL)PYRROLIDINE(1217831-54-3)
• EPA Substance Registry System: (R)-2-(4-CHLOROPHENYL)PYRROLIDINE(1217831-54-3)

Safety Data

• Hazardous Substances Data: 1217831-54-3(Hazardous Substances Data)

Usage

General Description

"(R)-2-(4-CHLOROPHENYL)PYRROLIDINE" is a chemical compound containing Chlorine - a halogen element, a pyrrolidine ring - a five-membered ring with one nitrogen atom, and a phenyl ring which is a functional group derived from benzene. This substance exists as an enantiomer, indicated by the (R) in its name, referring to its specific spatial arrangement. Its exact usage or function could vary widely, depending on its specific context in chemical reactions or processes. Containing both a chlorophenyl grouping and a pyrrolidine ring, it could have potential use in organic synthesis, pharmaceuticals, and medicinal chemistry. However, its precise properties, potential uses or biological activity would need to be researched or defined by specific studies or chemical analyses.

Upstream product

• 1218989-46-8 (R)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-chlorophenyl)-pyrrolidine 
• 1228560-90-4 C₁₀H₁₂ClN*ClH 
• 1354651-37-8 tert-butyl (4-(4-chlorophenyl)-4-oxobutyl)carbamate 
• 106-39-8 bromochlorobenzene 
• 22217-78-3 5-(4-chlorophenyl)-3,4-dihydro-2H-pyrrole 

Relevant articles and documents

Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks

The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex is reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodology is demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. (Figure presented.).

Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination

Chiral cyclic amines can be prepared via intramolecular reductive amination of N-Boc-protected amino ketones in a one-pot process. With the complex of iridium and f-spiroPhos as the catalyst, a range of N-Boc-protected amino ketones are smoothly transformed into chiral cyclic free amines in high yields and excellent enantioselectivities (up to 97% ee). Moreover, this method can also be successfully applied to the synthesis of a κ-opioid receptor selective antagonist, (S)-1.

Asymmetric synthesis of 2-arylpyrrolidines starting from γ-chloro N-(tert-butanesulfinyl)ketimines

The enantioselective reductive cyclization of γ-chloro N-(tert-butanesulfinyl)ketimines towards the short and efficient synthesis of (S)- and (R)-2-arylpyrrolidines (ee >99%) is described for the first time by treatment with LiBEt3H and subsequ