121839-94-9

Basic information

• Product Name: 2-(naphthalen-1-yl)-N-phenylpropanamide
• CAS NO: 121839-94-9
• Molecular Weight: 275.35
• Mol File: 121839-94-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(naphthalen-1-yl)-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(naphthalen-1-yl)-N-phenylpropanamide(121839-94-9)
• EPA Substance Registry System: 2-(naphthalen-1-yl)-N-phenylpropanamide(121839-94-9)

Safety Data

• Hazardous Substances Data: 121839-94-9(Hazardous Substances Data)

Upstream product

• 826-74-4 1-vinylnaphthalene 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 1402034-43-8 4,4,5,5-tetramethyl-2-(1-(naphthalen-1-yl)ethyl)-1,3,2-dioxaborolane 
• 103-71-9 phenyl isocyanate 
• 1117-96-0 Diazoethan 
• 879-18-5 naphthalene-1-carbonic acid chloride 

Relevant articles and documents

Asymmetric Markovnikov Hydroaminocarbonylation of Alkenes Enabled by Palladium-Monodentate Phosphoramidite Catalysis

A palladium-catalyzed asymmetric Markovnikov hydroaminocarbonylation of alkenes with anilines has been developed for the atom-economical synthesis of 2-substituted propanamides bearing an α-stereocenter. A novel phosphoramidite ligand L16 was discovered which exhibited very high reactivity and selectivity in the reaction. This asymmetric Markovnikov hydroaminocarbonylation employs readily available starting materials and tolerates a wide range of functional groups, thus providing a facile and straightforward method for the regio- and enantioselective synthesis of 2-substituted propanamides under ambient conditions. Mechanistic studies revealed that the reaction proceeds through a palladium hydride pathway.