1218779-89-5 Usage
Description
YN968D1 Hydrochloride is a small molecule multitargeted tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). It functions by inhibiting VEGF-mediated endothelial cell migration and proliferation, thus blocking new blood vessel formation in tumor tissue.
Uses
Used in Oncology:
YN968D1 Hydrochloride is used as an anticancer agent for its ability to selectively inhibit VEGFR2, which plays a crucial role in tumor angiogenesis. By blocking VEGF-mediated endothelial cell migration and proliferation, it can effectively inhibit the formation of new blood vessels in tumor tissue, thereby limiting the growth and spread of cancer cells.
Used in Combination Therapy:
YN968D1 Hydrochloride is used in combination with conventional chemotherapeutic drugs to enhance their efficacy in side population (SP) cells and ABCB1-overexpressing leukemia cells. Recent studies have shown that the addition of YN968D1 Hydrochloride can improve the chemo-sensitivity and therapeutic outcomes in these resistant cases, making it a valuable component in cancer treatment regimens.
Used in Drug Delivery Systems:
To optimize the delivery and bioavailability of YN968D1 Hydrochloride, various drug delivery systems have been developed. These systems, which may include organic and metallic nanoparticles, aim to improve the transport of the compound to target cells, enhancing its overall effectiveness and reducing potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1218779-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,8,7,7 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1218779-89:
(9*1)+(8*2)+(7*1)+(6*8)+(5*7)+(4*7)+(3*9)+(2*8)+(1*9)=195
195 % 10 = 5
So 1218779-89-5 is a valid CAS Registry Number.
